Artificial Intelligence and multi-omics of dynamic 3D imaging to
Unravel the molecular and cellular mechanisms driving tumor progession and resistance to treatment
BEHAV3D: an imaging and transcriptomics platform that unravels T cell antitumor activity - Nature BiotechnologyThis study reveals a high level of behavioral heterogeneity in engineered T cells that target tumor organoids. Behavior-guided transcriptomics identified the gene signatures of T cells with highly potent serial cytotoxicity. Integration of the organoid and T cell transcriptomic data enabled the design of patient-specific combinatorial treatment to achieve an optimized response to cancer immunotherapies.